Different calorie restriction treatments have similar anti-seizure efficacy

Different calorie restriction treatments have similar anti-seizure efficacy

PURPOSE Previous studies showed that a single oral administration of a synthetic ketone ester (1,3-butanediol acetoacetate diester, BD-AcAc2) could elevate blood ketones with promising acute anti-epileptic effects. The aim of the present work was to evaluate the tolerability of a prolonged administration of BD-AcAc2 and the anti-epileptic efficacy of such treatment. METHODS The threshold for ...

Calorie Restriction, Longevity and Cognitive Function

Calorie Restriction

Calorie restriction, or caloric restriction (CR), is a dietary regimen thought to improve health and slow the aging process in some animals and fungi by limiting dietary energy intake below the average needs. CR is the only dietary intervention which has been documented to increase both the median and maximum lifespan in a variety of species, among them rodents, yeast, fishes and dogs. The life...

Calorie Restriction à Lamarck

Epigenetic inheritance of resistance to exogenous nucleic acids via small interfering (si) RNA is well established in animal models. Rechavi et al. demonstrate epigenetic inheritance of a starvation-induced pattern of gene silencing caused by endogenous siRNAs and resulting in an increased longevity in the third generation progeny. Combined with recent findings in prokaryotes, these results sug...

Efficacy of antidepressants: similar but different.

Fountoulakis & Moller (2010) have re-analysed the Kirsch et al. (2008) meta-analysis of newer antidepressants and reached quite different conclusions to the original study. In particular they highlight that both venlafaxine and paroxetine exceed the NICE criteria for ‘clinical significance’ of 3 points on the Hamilton Rating Scale for Depression (HAMD) and that the Kirsch et al. analysis undere...